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A resident of Toulouse with American and French citizenship, Isabelle received her Licence (BA) in English and philosophy and her master's degree in literature from the University of Paris–La Sorbonne.
She has been on the teaching staff of New York's Marymount College and the Alliance Française in Los Angeles, California. Ms. Jaffe has taught French and English at several institutes and colleges in Toulouse and Avignon, and served as the supervisory director for the Centre International d'Etudes et de Loisirs, overseeing the pedagogy of the French language programs. She later directed the language and culture programs at the Centre d'Etudes Linguistiques d'Avignon.
In addition to her academic positions, Ms. Jaffe has worked as a cross-cultural consultant for several firms in the Toulouse area, including Aerospatiale. Her short stories have been published in literary journals in France and her plays have been produced in theaters in Toulouse.
Ms. Jaffe was a language instructor and assistant academic director for the SIT Toulouse program in the 1997–1998 academic year and was academic director in Toulouse from 1998 through 2014. In her role as academic director, Ms. Jaffe oversaw every aspect of the program. In addition to designing the program's academic and field-based components, she collaborated with an extensive network of individuals and organizations affiliated with the program and worked to ensure students’ academic needs were met. In the Fall of 2014, she was hired to set up and run CIEE's study center in Toulouse.